Location is everything

Location is everything

Location, Location, Location: Is Membrane Partitioning Everything When It Comes to Innate Immune Activation?

In the last twenty years, the general view of the plasma membrane has changed from a homogeneous arrangement of lipids to a mosaic of microdomains. It is currently thought that islands of highly ordered saturated lipids and cholesterol, which are laterally mobile, exist in the plane of the plasma membrane. Lipid rafts are thought to provide a means to explain the spatial segregation of certain ...

On the fight between excitation and inhibition: location is everything.

In the intact brain, neurons are constantly subjected to both excitatory and inhibitory inputs to their dendritic trees. Although it is accepted that the overall response of a neuron--its train of output spikes--depends on the balance of excitation and inhibition, we continue to lack specific knowledge of the rules that govern how excitatory and inhibitory inputs interact in space and time with...

Is Timing Everything?

Thank you Ben and AmSECT for organizing this conference. And thank you all for showing up on Saturday morning. My objectives for this presentation are to review the current knowledge of time spent below critical thresholds and more specifically the relationship between low oxygen delivery and organ function following cardiopulmonary bypass (CPB). Additionally, we will investigate the time–dose ...

Support is everything

Inadequate support for placement of balloons or stents continues to be a problem in interventional cardiology. We read with interest the report on MotherDaughter-Granddaughter Double Guide Liner Technique for Delivering Stents Past Multiple Extreme Angulations. The authors cleverly describe the use of a 6 French Guide Liner inside an 8 French Guide Liner to cross two difficult to cross saphenou...